基于大分子的Polymeric肿瘤靶向Tumor-TargetingDrugControlledRelease药物控释装载DrugLoad定位释放DrugReleaseTargeting树枝状聚合物装载DrugLoad胶束DendrimersMicelles聚合物-药物微脂囊偶联物LiposomesPolymer-drugconjugates主动配合基-受体叶酸activeLigand-receptorcRGD定位被动TargetingpassiveEPR效应EPREffect正常组织癌变部位外因内因磁场hydrazonebondspHPDEAEMA释放UVDrugRelease温度PNIPAM电场降解-s-s-点击化学超分子星形RAFT端基嵌段开环分子量分子设计多层ATRPMolecularDesignXiangLanWu,JongHoKimTumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiangLanWu,JongHoKimPEG-SS-PPS:Reduction-SensitiveDisulfideBlockCopolymerVesiclesforIntracellularDrugDeliveryPriyadarsiDe,SudershanR.Gondi,andBrentS.SumerlinFolate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyBhanuprasanthKoppolu,MS,MahamRahim,Developmentofmultiple-layerpolymericparticlesfortargetedandcontrolleddrugdeliveryβ-CDbasedHBPCoreSiSiSiSiOOOSiOSiOSiHNONH2SiHNH2NSiSiOSiOSiHOOHNSiH2NSiSiOSiOSiHOOSiHNHH2NgraftedPNIPAMShellThermo-ResponsiveHyperbranchedpoly(β-CD)s-g-PNIPAMPolymericTumor-TargetingDrugControlledReleaseThankyou!NorthwesternPolytechnicUniversity
