2022年医学专题—博士生课程5(1)-细胞因子.ppt

CytokineCytockinesarelow-molecular-weightregulatoryproteinsorglycoproteinssecretedbywhitebloodcellsandvariouscells(vascularendothelialcell,epidermiccellandfibroblast)inbodyinresponsetoanumberofstimuli.8-30KDCK-CKRsMjIL-8第一页，共八十九页。Example:CytokinescanexertdifferentactionsIL-2第三页，共八十九页。Proliferation,survivalChemokinesLeukocyterecruitmentAcutephaseproteins,IL-6TNFIL-33Propertiesofcytokines细胞因子调节(tiáojié)IgG类别转换多效性重叠(chóngdié)性协同性拮抗(jiénɡ)性第四页，共八十九页。Cytokinesduringhematopoiesis第六页，共八十九页。Cytokinesinterleukin,IL（白细胞介素）colonystimulatingfactor,CSF（集落刺激因子(yīnzǐ)）interferon,IFN（干扰素）tumornecrosisfactor,TNF（肿瘤坏死因子）Chemokine,CK（趋化因子）growthfactor,GF（生长因子）第七页，共八十九页。Cytokinesoftheinnateandadaptiveimmunesystem第八页，共八十九页。第九页，共八十九页。CytokinesofinnateimmunesystemTNF,IL-1andIL-6:pleiotropicmediatorsofinflammation(activatorsofendothelium,immunecells,liverandbrain)Chemokines:regulatorsofimmunecelladhesionatinfectionsitesIL-12:inducerofIFN-γ,increaseofcytotoxicactivityTypeIIFN:inducersofantiviralstate第十页，共八十九页。InterleukinInterleukinsaresecretedbysomeleukocytesandactuponotherleukocytes,IL-1~IL-35havebeenidentified.第十一页，共八十九页。第十二页，共八十九页。Interleukin-1,IL-1第十三页，共八十九页。Tumornecrosisfactor,TNFThereleaseofTNF-bymacrophagesinduceslocalprotectiveeffects,butTNF-第十四页，共八十九页。Chemokinechemokines,agroupoflow-molecular-weightcytokinesincludinginterleukin8,thataffectchemotaxisandotheraspectsofleukocytebehavior.第十五页，共八十九页。1999年国际(guójì)命名委员会根据CK的结构特征命名依据N端前两个半胱氨酸(Cys)的相对位置不同分为:CCK及CKR分类XCRCCCCRCXCCXCRCX3CCX3CR第十六页，共八十九页。第十七页，共八十九页。第十八页，共八十九页。IL-12•IL-12producedbymacrophagesanddendriticcellsisakeycytokinetofightintracellularmicrobes(bacteriaandviruses)•IL-12inducesIFN-γ,anactivatorofmacrophages(killingofphagocytosedmicrobes)andTh1celldifferentiation•IL-12alsoincreasescytotoxicactivityofCD8andNKcells第十九页，共八十九页。typeIInterferonThecytokinesthatresistviralinfection,andinterfereviralreplication,includingIFN,IFN,IFNε,IFNω,IFNκ(typeI);IFN(typeII)AntiviraleffectsofTypeIInterferons(IFN-第二十页，共八十九页。第二十一页，共八十九页。Integrativesignalingofcytokinesduringinnateimmuneresponses第二十二页，共八十九页。CytokinesofadaptiveimmunesystemIL-2:prototypiclymphocytegrowthfactorIL-4:inducerofTh2cells,BcelldifferentitationfactorIFN-γ:inducerofTh1cells第二十三页，共八十九页。IL-2(又称T细胞生长因子,TCGF)：细胞来源：主要由T细胞产生。作用方式：以自分泌和旁分泌方式发挥效应。主要生物学功能：（1）活化T细胞，促进细胞因子产生；（2）刺激NK细胞增殖，增强NK杀伤活性及产生细胞因子；诱导LAK细胞产生（3）促进B细胞增殖和分泌抗体(kàngtǐ)；（4）激活巨噬细胞。第二十四页，共八十九页。第二十五页，共八十九页。IL-4IL-4inducesIsotypeswitchingagainstextracellularpathogens,suchashelminthsandathropodes第二十六页，共八十九页。PleiotropicactivitiesofIFN-γIFN-γissecretedbyactivatedTcellsafterIL-12stimulationduringantimicrobialresponses(intracellularbacteriaandviruses)Th1cellshelpBcellsotypeswitchtoIgGforcomplementbindingandFc-bindingonphagocytesstrongmacrophageactivator第二十七页，共八十九页。Anti-inflammatorycytokinesIL-10IL-10:count...